Research Papers of ACTAVELIT

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Volume : 1 | Issue : 3

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Adrenomedullin level in neonatal hyperbilirubinemia

Yasser K. Rashed, Mohamed A. El Guindi, Magdy A. Saber, Ahmed A. Al-Shaarawy and Doaa T. Mohammad
DOI Number :      Page number :1-10
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Cellular and molecular mechanisms responsible for neurotoxicity have not yet been determined despite too many studies conducted. Recent studies show that bilirubin may create oxidative stress. AM decreases endothelial permeability by increasing transendothelial electrical resistance (TEER), and with cAMP increase, it plays an important
role in the regulation of this barrier, to investigate the relation between serum bilirubin and AM. Case control study included seventy neonates divided into two groups jaundiced and normal control groups. Complete Blood Count (CBC), liver function tests, kidney function tests and Serum adrenomedullin: measured by Human Adrenomedullin Enzyme Linked Immunosorbent Assay for boyh groups. Serum AM levels Serum adrenomedullin level was 48.64 ± 0.39 ng/ L in jaundiced group (group 1) while in the control group (group 2), the level was 1.37 ± 0.01 ng/ (p < 0.01). We can conclude that the role, effects and physiopathological basis of AM in neonatal hyperbilirubinemia should be established especially with further animal studies.

The role of diet and life style modifications in the prevalence of metabolic disorders and progression of autoimmune diseases

A.Krishna sailaja
DOI Number :      Page number :11-15
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Diet and life style modifications play an important role in the prevalence of several metabolic
disorders and progression of autoimmune diseases. Blood pressure, heart attack, type2 diabetes are strongly associated with life style modifications. Type 2 diabetes can be explained by means of thrifty phenotype hypothesis. It can be programmed in the utero itself. In recent years many specialized diets have gained popularity among some people with arthritis. In this review the significance of diet in the incidence of diseases and control of disease was discussed in detail. Diet to be taken to control Ankylosing spondylitis and rheumatoid arthritis was also explained.

Relationship of serum total homocysteine and traditional risk factors along with lipid profile in gujarati patients with acute myocardial infarction

Varsha Galani, Rachna Jagiwala, Sunil Karna
DOI Number :      Page number :16-25
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Homocysteine is well established as a novel risk factor for myocardial infarction. The present cross sectional study was designed to investigate the possible relationship of serum total homocysteine, lipid profile with acute myocardial infarction (MI) in the Gujarati patients from India. 30 subjects admitted and diagnosed with MI from Shree Krishna Hospital, Karamsad, Gujarat were enrolled in the study after obtaining written informed consent from eligible patients. Serum total homocysteine, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) were measured within 24 hrs of the event of acute MI. Homocysteine was assayed by Fluorescence Polarization Immuno Assay method, fasting lipid profile and other traditional risk factors were compared. Results indicated that mean serum homocysteine was found 31.46 ± 4.77 μmol/L. Smoking as the predominant risk factor was found in study population. Hyperhomocysteinemia was significantly high in smokers and male gender. Mean values of LDL and TG were found to be borderline elevated in study population. However, there was no significant correlation found between homocysteine and lipid profile. It is concluded that homocysteine is emerged as a significant important risk factor for acute MI patients. It was significantly correlated with smoking and male MI patients while not significantly correlated with other traditional risk factors and lipid profile of the patient.

Varietal performance of turmeric (curcuma longa l.) Under southern parts of rajasthan

Virendra Singh, S.K. Acharya, D.K. Sarolia and Deepesh Panchori
DOI Number :      Page number :26-29
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Seven genotype of turmeric (Curcuma longa L.) were evaluated under irrigated condition for two consecutive years at Fruit Research Station, Banswara (Rajasthan). The genotype varied in their production potential, growth characters and curcumin content (Plant height, number of tiller per plant, single plant yield (Kg), yield (q/ha) and curcumin content (g/100g)). Among varieties evaluated, pooled data revealed that variety Suroma produced maximum plant height (134.17 cm), number of tillers per plant (5.39), single plant yield (0.431 kg) and yield per hectare fresh rhizome 231.11 q/ha and it was at par with the production of Roma (216.40 q/ha). These two varieties viz., Suroma and Roma were significantly superior among all the varieties during both the seasons and are suitable for general cultivation in the southern parts of Rajasthan, whereas, Pratibha variety contains highest curcumin (3.12 g/100g) followed by Roma (2.69 g/100g).

Preliminary phytochemical screening and anti-inflammatory studies of the methanol extract of maytenus senegalensis (lam.) Exell (celastraceae)

Ahmed Abubakar Murjanatu, Mohammed Garba Magaji
DOI Number :      Page number :30-33
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The leaf methanolic extract of Maytenus senegalensis (Lam.) Exell was investigated for antiinflammatory activity using carrageenan induced paw oedema and the methanolic extract produced moderate anti-inflammatory effect significantly (p˂0.05) at all doses tested. The preliminary phytochemical screening carried out reveals the presence of alkaloid, saponins, tannins, cardiac glycosides, carbohydrates, and flavonoids while anthraquinones tested negative. The results obtained suggested the extract to exhibit effective antiinflammatory
activity which may be due to the presence of the variable phytochemical constituents that are
present in the plant’s extract.

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