Research Papers of AJBPR
Volume : 1 | Issue : 1
Wheat bran is a low cost biosorbent that has been used for the removal of heavy metal ions from highway runoff. It is noted that increase in Pb2+ concentration and pH, caused the increase in adsorption capacity of wheat bran. In relation to this, a decrease in wheat bran dose results in a higher metal loading on the wheat bran. The adsorption data fitted the Langmuir and Freundlich model. In this investigation, order of heavy metal removal by wheat bran is Pb2+ > Cu2+ > Zn2+. A high concentration of co-existing ions such as Ca2+ and Mg2+ depresses the adsorption of heavy metal. Dissolved organic matter (DOM) has a significant influence on metal adsorption. In column studies, a long breakthrough time is observed for heavy metals according to the ion selectivity on wheat bran. The metal adsorption capacity per wheat bran mass is found more in batch studiesthan in column studies. Flushing of the column saturated with heavy metals by 0.1M CaCl2 solution results in the elution of a highly concentrated metal within shortened pore volumes, indicating that wheat bran repeatedlybe utilized for the treatment of heavy metals.
Hydrotropy is the term that has been used to designate the increase in aqueous solubility of poorly water-soluble compounds in hydrotropic solutions. In the present investigation mixed hydrotropicsolubilization phenomenon was employed in simultaneous estimation of solubilize poorly water-soluble drugs aceclofenac and paracetamol from bulk powder and its tablet dosage form. Aceclofenac showed maximum absorbance at 274.5 nm, whereas paracetamol showed maximum absorbance at 261.5 nm. Thesolubility of both aceclofenac and paracetamol was enhanced to greater extent in mixed hydrotropic solution of 30% urea with 20% sodium citrate. Both the drugs showed linearity in the concentration range
of 5-40 μg/mL and 4-40 μg/mL. Both the drugs showed good regression values of 0.9955 for aceclofenac and 0.9943 for paracetamol at their respective wave lengths. The estimated label claim was found to be 102.43±0.264 mg for aceclofenac and 99.28±0.681 for paracetamol with less standard deviation. The
results of recovery study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method. The value of LOD and LOQ was found to be 0.2129 μg/ml and 0.6451μg/ml for aceclofenac and 0.2735 μg/mL and 0.8290 μg/mL that indicated good sensitivity of proposed method. The proposed method explains a new, simple, cost effective, accurate, and precise simultaneous estimation of aceclofenac and paracetamol using the mixed hydrotropic solubilization phenomenon that can be successfully adopted for routine analysis of aceclofenac and paracetamol in tablet dosage form.