Diabetes Mellitus (DM) is one of the largest health emergencies and highest challenges in this century, because in the last two decades the number of patients with Diabetes has increased to almost double, currently affecting lakhs of people all over the world. One of the most serious consequences of this increase is the onset of type 2 Diabetes in children, adolescents and young people, the main causes being an unhealthy lifestyle: unhealthy food, sedentary lifestyle, which, most of the times, lead to obesity. Diabetes Mellitus is one of the main causative factor of death all over the world, a reason for which there are required prevention programs worldwide along with some natural solutions through plants. Many plants have shown potential effect as anti-hyperglycemic agents in Indian system of medicine, including Ayurveda to effectively manage Diabetes and Pre-diabetes. One such important plant is kundru.
Leaves of kundru or ivy gourd; Coccinia indica, a member of Cucurbitaceae family, is a common plant of India, which is being used by Indians for centuries as a food as well as medicine. The therapeutic potential of kundru against Madhumeha or diabetes mellitus is due to its multi-dimensional effects, it (1) Increases the Level of Plasma Insulin, (2) Increases Liver Hexokinase activity, (3) Depression of the hepatic gluconeogenic enzymes, (4) Shows β-cell regeneration and (5) increases Glycogen synthetase activity. The various scientific studies have established the effectiveness of kundru and simultaneously provides sufficient ground for the development of potential anti-hyperglycemic drug.