Diabetes Mellitus (DM) is one of the largest health emergencies and highest challenges in this century, because in the last two decades the number of patients with Diabetes has increased to almost double, currently affecting lakhs of people all over the world. One of the most serious consequences of this increase is the onset of type 2 Diabetes in children, adolescents and young people, the main causes being an unhealthy lifestyle: unhealthy food, sedentary lifestyle, which, most of the times, lead to obesity. Diabetes Mellitus is one of the main causative factor of death all over the world, a reason for which there are required prevention programs worldwide along with some natural solutions through plants. Many plants have shown potential effect as anti-hyperglycemic agents in Indian system of medicine, including Ayurveda to effectively manage Diabetes and Pre-diabetes. One such important plant is kundru.
Leaves of kundru or ivy gourd; Coccinia indica, a member of Cucurbitaceae family, is a common plant of India, which is being used by Indians for centuries as a food as well as medicine. The therapeutic potential of kundru against Madhumeha or diabetes mellitus is due to its multi-dimensional effects, it (1) Increases the Level of Plasma Insulin, (2) Increases Liver Hexokinase activity, (3) Depression of the hepatic gluconeogenic enzymes, (4) Shows β-cell regeneration and (5) increases Glycogen synthetase activity. The various scientific studies have established the effectiveness of kundru and simultaneously provides sufficient ground for the development of potential anti-hyperglycemic drug.
The present work aims on a series of 3,5-disubstituted isoxazole derivatives of α-β dibromochalcones which were synthesized by the reaction of α-β dibromochalcones with hydroxylamine hydrochloride. Various α-β dibromochalcones were prepared by the reaction of respective chalcones with TetraButylAmmoniumTribromide (TBABr3) which causes regioselective bromination of chalcones and gives high yield without polymerization. The synthesized compounds were characterized and subsequently evaluated for anti-inflammatory and antioxidant properties.
Drugs obtained from the plants and their semi-synthetic derivatives have been recognized as the core pharmacoactive moiety for the diverse biological activities. The importance of the natural product based drug has generated interest to develop efficient extraction methods of these important classes of compounds to generate new therapeutic leads for various diseases. The biological activities of one of the privileged plant have been summarized in a few review articles. In view of these, the aim of this review is to provide a platform to know the importance of the Ocimum Genus, which is widely known as Tulsi in the entire Indian population. A keen Attention has been focused on those literature reports wherein the use of Tulsi and cancer is described. The use of plant would be beneficial for the drug discovery scientist to develop an efficient formulation of the crude drug, which will be a magical therapeutic agent, with the many advantages.